Kinetics of central macular thickness reduction in patients with macular edema after intravitreal drug therapy

نویسندگان

  • Lingmin He
  • Annie Chan
  • Theodore Leng
  • Mark S Blumenkranz
چکیده

BACKGROUND The purpose of this study was to characterize central macular thickness and retinal volume following intravitreal injections using time domain and spectral domain optical coherence tomography (TD-OCT and SD-OCT, respectively). METHODS Nine patients with macular edema secondary to diabetes or retinal vein occlusion treated with intravitreal triamcinolone 4.0 mg and/or bevacizumab 1.25 mg were enrolled. Central macular thickness and volume was measured by SD-OCT and TD-OCT scan at baseline, and 1, 3, 6, 24, 48 hours, and 1 week postinjection. RESULTS Equations were derived to describe central macular thickness and volume reduction in the hours following intravitreal injection. Measurements of central macular thickness by SD-OCT were significantly reduced by 3 hours (P = 0.03) and retinal volume by 6 hours (P = 0.03). Central macular thickness measured 40.9 (28.6-53.2) μm thicker on the SD-OCT instrument while volume measured 3.47 (3.27-3.66) mm(3) higher. CONCLUSION Significant central macular thickness and volume reductions occur in the first hours after injection with triamcinolone and/or bevacizumab.

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عنوان ژورنال:

دوره 5  شماره 

صفحات  -

تاریخ انتشار 2011